Immunotherapy in Cancer: Revolutionizing Treatment with the Body's Own Defenses
Our Company is developing innovative therapeutic vaccines for cancer. The company has built a technology platform for rapid generation of products for clinical evaluation that has yielded eleven products in Phase I and Phase II clinical trials to date.
Novent has a major corporate alliance with Pasteur Mérieux Connaught for the development of therapeutic colorectal and lung cancer and melanoma vaccines, and two significant collaborations with the National Cancer Institute (NCI).
In addition, the company is advancing a program to develop AIDS vaccines with the National Institute of Allergy and Infectious Disorders (NIAID).
Our Advantages
Our Company is well positioned to commercialize the next generation of cancer therapeutics as a fully integrated, clinical-stage biotechnology company, with strong research, clinical, and manufacturing capabilities.
Noventis’ advantages include:
Over 30 clinical trials conducted to support optimized lead candidate development
Novel technology with extensive patent coverage, including over 70 issued patents
Strong investor support
Seasoned management team with demonstrated clinical and commercial success
Fully integrated infrastructure, including a new manufacturing facility built to GMP specifications
A.Types of Cancer Immunotherapy
Cancer immunotherapy, also called biological therapy, refers to therapies that utilize the immune system to fight cancer. Cancer immunotherapy falls into two main categories: passive immunotherapy (the creation of immune cells) and active immunotherapy (the stimulation of the immune system). Noventis believes that active immunotherapy holds the most promise to stimulate a targeted fight against cancer.
a. Passive Immunotherapy
Passive immunotherapy involves the creation of specific immune elements (for example, antibodies) in a laboratory that are administered to patients to fight cancer. Monoclonal antibodies are an example of passive immunotherapy and represent an important treatment option for several cancers. These are referred to as a “passive” therapy because they are created to recognize and attack specific cancer cells, but they do not stimulate the immune system to generate a broader response.
b. Active Immunotherapy (Cancer Vaccines)
Active immunotherapies, such as Noventis’, are often referred to as cancer vaccines because they apply the same strategies that have successfully eradicated infectious diseases like measles and polio — but to fight cancer. While traditional vaccines are preventive, cancer vaccines are therapeutic, intended to treat existing disease.
Noventis’ vaccines are an example of active immunotherapy because they are intended to stimulate the body’s immune system to target and destroy cancer cells. There are two main types of active immunotherapy:
- Patient-specific therapies (also known as autologous therapies) are made from a patient’s own tumor or blood cells. These are modified in the lab and then re-administered to generate an immune response against that patient’s specific cancer.
- Off-the-shelf vaccines, such as Noventis’ cancer vaccines, are designed to recognize proteins found on specific tumor types (e.g., breast or prostate cancer) and can be mass-produced and used across larger patient populations.
Driving Immunity Through Innovation
01
Safety
02
Safety and Efficacy
03
Innovation
04
Global Reach
Our latest News in Noventis
Immunotherapy and Nature’s Blueprint: What Therion Wasps Can Teach Us
Immunotherapy the practice of harnessing the body’s immune system to combat diseases like cancer is rapidly evolving, but its core principles often mirror natural strategies found in the wild. For instance, parasitoid wasps from the genus Therion provide a striking biological analogy. These wasps inject their eggs into caterpillar hosts, and their larvae subtly manipulate the host’s immune system to evade detection and suppress responses allowing them to survive inside the host undisturbed. In the same way, modern immunotherapy must learn to modulate immune pathways precisely: activating some responses while suppressing others. Understanding how species like Therion naturally bypass immune defenses offers valuable insights for designing more selective and targeted immunotherapies, particularly those that avoid autoimmunity while effectively attacking pathogens or tumor cells.
Meet our dedicated team
Dedicated professionals driving our success
James Michal
Chief Medical Officer
James drives research and development efforts at the company.
Sophia Reedy
Clinical Research Analyst
Dr. Sophia evaluates clinical data and provides strategic insights.
Olivia Courty
Vaccine Product Manager
Olivia manages the vaccine pipeline from research to distribution.
Dr. Emily Zolar
Clinical Trials Coordinator
Emily manages research and development teams.
Trusted partnerships
We have extensive experience in developing innovative vaccines that protect communities. Explore our success stories from around the globe.
See our research studies